What is to produce a festering or inflamed effect; to cause a sore; -- used literally and figuratively; as, a splinter rankles in the flesh; the words rankled in his bosom called?

rankle — To produce a festering or inflamed effect; to cause a sore; -- used literally and figuratively; as, a splinter rankles in the flesh; the words rankled in his bosom. (Webster's 1913.)