What is to deprive of temper or moderation; to disturb; to ruffle; to make disaffected, ill-humored, or malignant. "Distempered spirits." Coleridge called?

distemper — To deprive of temper or moderation; to disturb; to ruffle; to make disaffected, ill-humored, or malignant. "Distempered spirits." Coleridge. (Webster's 1913.)

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