What does "malignance" mean?

Malignance: Unfavorableness; evil nature. The malignancy of my fate might perhaps distemner yours. Shak.

Additional senses

  1. 2.(Med.) Virulence; tendency to a fatal issue; as, the malignancy of an ulcer or of a fever.
  2. 3.The state of being a malignant. See Malice.

Sources