What does "estrange" mean?

Estrange: To divert from its original use or purpose, or from its former possessor; to alienate. They . . . have estranged this place, and have burned incense in it unto other gods. Jer. xix.

Additional senses

  1. 2.3. To alienate the affections or confidence of; to turn from attachment to enmity or indifference. I do not know, to this hour, what it is that has estranged him from me. Pope. He . . . had pretended to be estranged from the Whigs, and had promised to act as a spy upon them. Macaulay.

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