What does "despair" mean?

Additional senses

1. 2.To give up as beyond hope or expectation; to despair of. [Obs.] I would not despair the greatest design that could be attempted. Milton.
2. 3.To cause to despair. [Obs.] Sir W. Williams.
3. 4.Loss of hope; utter hopelessness; complete despondency. We in dark dreams are tossing to and fro, Pine with regret, or sicken with despair. Keble. Before he [Bunyan] was ten, his sports were interrupted by fits of remorse and despair. Macaulay.
4. 5.That which is despaired of. "The mere despair of surgery he cures." Shak.